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Successful integration of venetoclax into AYA (CALGB 10403) directed therapy for T/myeloid mixed-phenotype acute leukemia with extramedullary disease: A case report and literature review

Fatima Al Ali*; Mansour Alfayez; Tarek Owaidah; Ayman Saad; Amr Hanbali

    Mixed-Phenotype Acute Leukemia (MPAL) is a rare and heterogeneous disorder characterized by the co-expression of lineage-defining antigens from more than one hematopoietic lineage, typically myeloid with B- or T-lymphoid markers.


Concurrent Therapy of Hepatitis C and Primary CNS Lymphoma: A Case Report

K. Xhaxho*; E. Aydilek; R. Akdas; K. Becker; H. Schwörer; T. Huckhagel; L. Stork; C. Stadelmann; G. Wulf; N. Brökers

    At diagnosis of primary central nervous system lymphoma (PCNSL), the patient was tested positive for hepatitis C. Curative therapy for cerebral lymphoma includes high-dose methotrexate. Direct antiretroviral (DAA) drugs are highly effective in the treatment of hepatitis C.


A Rare Case of an Acquired Isolated Factor VII Deficiency Discovered in a 23-Year-Old Female Patient

Zahra Kmira*; Sassi Nedia; Ben Yahya Noura; Ncibi Seif; Greisha Ahmed; Mootameri Wided; Bouteraa Walid; Zaier Monia; Ben Youssef Yosra; Brahem Nejia; Haifa Regaieg; Khelif Abderrahim

    Background: Factor VII (FVII) deficiency, a rare bleeding disorder, can manifest as an autosomal recessive congenital or an acquired coagulopathy. Acquired FVII deficiency, although infrequently reported, presents unique challenges in understanding its mechanisms and identifying underlying causes.


Some Markers of Coagulation and Glycemic Control in Type 2 Diabetes Mellitus Patients Based on Gender

Alphonsus Ogbonna Ogbuabor*; Kinsley Ogbonna Ugwu; Basil Ifeanyi Ugwu

    Background: The burden of type 2 diabetes mellitus (T2DM) is increasing worldwide and. It is a leading cause. Due to lack of funds and poor healthcare system, Sub-Saharan Africa is the worst affected with Nigeria bearing the greatest burden for the region. A major factor underlying the development of complication in type 2 diabetes is poor glycemic control and coagulation activation.


Validation of Statistical Quality Controls to Improve HCV Detection: An Efficient Approach for Accurate Diagnosis

Shahid Nadeem; Ali Haider*; Hannana Maryum; Mahnoor Fatima; Umair Waqas; Faiza Maryum; Usman Baig

    HCV is the RNA enveloped virus belonging to the family of flavivirus, causing serious hepatic problems all over the world. While screening for HCV, many of the results false negative or false positive which reach chronic stages of the infection and eventually cancer


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