IMPACT FACTOR: 1.4
Short Name: Ann Oncol Case Rep
Publisher: MedDocs Publishers LLC
BRCA1 and BRCA2 mutations are strongly associated with homologous recombination deficiency in ovarian cancer and predict response to poly (ADP-ribose) Polymerase (PARP) inhibitors [1,2]. However, tumors lacking detectable BRCA mutations may still demonstrate a “BRCAness” phenotype through alternative molecular mechanisms such as BRCA1 promoter methylation [3,4].
Basal Cell Carcinoma, primarily occurring due to sunlight exposure, radiation, arsenic, immunosuppression or inherited conditions like Xeroderma pigmentosum, mostly present in sun-exposed areas of the head and neck but can also present elsewhere.
Targeted Osmotic Lysis (TOL) has been recently proposed as a novel, safe, and effective method for treating advanced carcinomas. The technique takes advantage of the finding that carcinomas greatly over-express Voltage-Gated Sodium Channels (VGSCs)
Malignant melanomas are often misdiagnosed or discounted when the disease is present in early, more treatable stages. When present during later stages of disease treatment options tend to be more limited, less effective, and prone to association with significant adverse effects.
Blood is a red, dark and thick fluid, with a salty taste and particular scent, that streams through the blood vessels and the heart. It passes through all parts of the body, supplies it with supplements and oxygen, and carries destructive substances to the organs that discharge or neutralize them.
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