IMPACT FACTOR: 1.4
Enfortumab vedotin is an Antibody-Drug Conjugate (ADC) used to treat urothelial cancer. It has recently been associated with reports of Stevens Johnson syndrome/Toxic Epidermal Necrolysis (TEN). I report the clinical case of a 74-year-old man who developed an extensive skin lesion, clinically mimicking TEN.
Single nucleotide polymorphisms are a sort of genetic variations, have been identified in numerous genes that linked to various cancer types. SNPs in exon regions of hub cellular of genes that influence gene expression
Chordomas are rare tumors that grow slowly, tend to recur locally and seldom metastasize. They originate from residual primitive notochordal tissues along the axial skeleton and are typically found in the sacrococcygeal region (50%), clivus (35%), and vertebral bodies (15%). The median reported survival is 6.29 years with a 10-year survival rate of 39.9%.
The relationship of mutations in the BRCA 2 gene has been established with some types of tumors, especially breast, ovarian, prostate, or pancreatic cancer. However, the relationship between the development of colorectal tumors and type of genetic alteration is not entirely clear.
Advanced laryngeal cancers are conventionally treated by total laryngectomy but surgical intervention has a profound impact on quality of life. Role of radiotherapy in laryngeal cancer with extensive extra laryngeal spread is limited. Therefore, we did a study of the case series to investigate the survival outcomes and laryngeal preservation after radical radiotherapy in advanced laryngeal carcinomas with extensive extra laryngeal spread.
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